mouse BRCC3 Over-expression AAV
This is an AAV expressing Mouse Brcc3.
AAV-254071
AAV-m-BRCC3
Ready-to-use AAV expressing Mouse Brcc3 (BRCA1/BRCA2-containing complex, subunit 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C6.1A
Description (Vector)
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
Gene ID
210766
Gene Name (Vector)
BRCA1/BRCA2-containing complex, subunit 3
Gene Symbol
Brcc3
ORF Size (aa)
876
ORF Size (bp)
876 bp
RefSeq ID
NM_145956
RefSeq Synonyms
NM_145956, NM_001166459, NM_001166457, BC048179, BC021313,
Species
mouse
UniGene ID
Mm.226957
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.