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human OBSCN Over-expression AAV

Name 
AAV-h-OBSCN
Cat No 
AAV-233511
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human OBSCN.

AAV-233511
AAV-h-OBSCN

Ready-to-use AAV expressing Human OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARHGEF30; UNC89
Description (Vector)
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
84033
Gene Name (Vector)
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Gene Symbol
OBSCN
HGNC ID
HGNC:15719
ORF Size (aa)
501
RefSeq ID
NM_052843
RefSeq Synonyms
NM_052843, NM_001271223, NM_001098623, BC098262,
Species
human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.