human ZAP70 Over-expression AAV

70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; IMD48; SRK; STCD; STD; syk-related tyrosine kinase; tyrosine-protein kinase ZAP-70; TZK; ZAP-70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD

ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation.

ZAP70 encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

7535

zeta chain of T cell receptor associated protein kinase 70

zeta chain of T cell receptor associated protein kinase 70

ZAP70

HGNC:12858

9606.0

1482

1482 bp

Tyrosine-protein kinase ZAP-70

NM_001079

NM_207519, NM_001079, BC053878, BC039039,

Apoptosis,B-cell Receptor Signaling,EPO Signaling,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Neurobiology,NF-kB Signaling,Phospho-specific,Prolactin Signaling,Signal Transduction,T-cell Receptor Signaling,VEGF Signaling

signal_transduction,cell_biology,immunology,signal_transduction,cell_biology,neurobiology,signal_transduction,immunology,cell_biology,signal_transduction,immunology

human

ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation.

Hs.234569

P43403