human XIAP Over-expression AAV

Name 
AAV-h-XIAP
Cat No 
AAV-227883
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human XIAP.

AAV-227883
AAV-h-XIAP

Ready-to-use AAV expressing Human XIAP (X-linked inhibitor of apoptosis). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2
Description (Vector)
XIAP encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Gene ID
331
Gene Name (Vector)
X-linked inhibitor of apoptosis
Gene Symbol
XIAP
HGNC ID
HGNC:592
ORF Size (aa)
1494
ORF Size (bp)
1494 bp
RefSeq ID
NM_001167
RefSeq Synonyms
NM_001204401, NM_001167, BC032729,
Species
human
UniGene ID
Hs.356076

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.