human UNC13D Over-expression AAV

Name 
AAV-h-UNC13D
Cat No 
AAV-227185
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human UNC13D.

AAV-227185
AAV-h-UNC13D

Ready-to-use AAV expressing Human UNC13D (unc-13 homolog D). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FHL3; HLH3; HPLH3; Munc13-4
Description (Vector)
UNC13D encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Gene ID
201294
Gene Name (Vector)
unc-13 homolog D
Gene Symbol
UNC13D
HGNC ID
HGNC:23147
ORF Size (aa)
3273
ORF Size (bp)
3273 bp
RefSeq ID
NM_199242
RefSeq Synonyms
NM_199242, BC067084,
Species
human
UniGene ID
Hs.41045

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.