human UCHL5 Over-expression AAV

Name 
AAV-h-UCHL5
Cat No 
AAV-227104
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human UCHL5.

AAV-227104
AAV-h-UCHL5

Ready-to-use AAV expressing Human UCHL5 (ubiquitin C-terminal hydrolase L5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CGI-70; INO80 complex subunit R; INO80R; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin thioesterase L5; UCH37; UCH-L5
Description (eCommerce)
Ubiquitin C-terminal hydrolase UCH37 is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. UCH37 is a deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. It is a putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5K5].
Gene ID
51377
Gene Name (eCommerce)
ubiquitin C-terminal hydrolase L5
Gene Name (Vector)
ubiquitin C-terminal hydrolase L5
Gene Symbol
UCHL5
HGNC ID
HGNC:19678
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
987
ORF Size (bp)
987 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase isozyme L5
RefSeq ID
NM_015984
RefSeq Synonyms
NM_015984, NM_001199263, NM_001199262, NM_001199261, BC025369, BC015521,
Research Areas
Brain Development,Cardiology,Cardiovascular,Complexome,DNA Damage/Repair,Neurobiology,Neurodevelopment,Proteasome,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Ubiquitination
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cardiovascular,cell_biology,genetics,transcription_translation,neurobiology,developmental_biology,cell_biology,signal_transduction,immunology,genetics,transcription_translation
Species
human
Target Sentence
Ubiquitin C-terminal hydrolase UCH37 is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. UCH37 is a deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. It is a putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5K5].
UniGene ID
Hs.591458
UniProt ID (eCommerce)
Q9Y5K5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.