human TXNRD1 Over-expression AAV

Name 
AAV-h-TXNRD1
Cat No 
AAV-226929
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TXNRD1.

AAV-226929
AAV-h-TXNRD1

Ready-to-use AAV expressing Human TXNRD1 (thioredoxin reductase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; KM-102-derived reductase-like factor; oxidoreductase; testis tissue sperm-binding protein Li 46a; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; thioredoxin reductase TR1; TR; TR1; TRXR1; TXNR
Description (eCommerce)
Thioredoxin Reductase 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16881].
Description (Vector)
TXNRD1 encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
Gene ID
7296
Gene Name (eCommerce)
thioredoxin reductase 1
Gene Name (Vector)
thioredoxin reductase 1
Gene Symbol
TXNRD1
HGNC ID
HGNC:12437
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
Protein Name (eCommerce)
Thioredoxin reductase 1, cytoplasmic
RefSeq ID
NM_182743
RefSeq Synonyms
NM_182743, NM_182742, NM_182729, NM_003330, NM_001261446, NM_001261445, NM_001093771, BC018122,
Research Areas
Immunology,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology,metabolism,cell_biology,signal_transduction,immunology
Species
human
Target Sentence
Thioredoxin Reductase 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16881].
UniGene ID
Hs.708065
UniProt ID (eCommerce)
Q16881

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.