human TBCC Over-expression AAV

Name 
AAV-h-TBCC
Cat No 
AAV-225116
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TBCC.

AAV-225116
AAV-h-TBCC

Ready-to-use AAV expressing Human TBCC (tubulin folding cofactor C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CFC; Tubulin-folding cofactor C; tubulin-specific chaperone C
Description (eCommerce)
Tubulin-folding cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state [taken from NCBI Entrez Gene (Gene ID: 6903)].
Description (Vector)
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Gene ID
6903
Gene Name (eCommerce)
tubulin folding cofactor C
Gene Name (Vector)
tubulin folding cofactor C
Gene Symbol
TBCC
HGNC ID
HGNC:11580
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1041
ORF Size (bp)
1041 bp
Protein Name (eCommerce)
Tubulin-specific chaperone C
RefSeq ID
NM_003192
RefSeq Synonyms
NM_003192, BC020170, BC017479,
Research Areas
Cytoskeleton,Metabolism/Metabolic Process,Protein Folding,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
Tubulin-folding cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state [taken from NCBI Entrez Gene (Gene ID: 6903)].
UniGene ID
Hs.75064
UniProt ID (eCommerce)
Q15814

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.