human TAX1BP1 Over-expression AAV

Name 
AAV-h-TAX1BP1
Cat No 
AAV-225050
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TAX1BP1.

AAV-225050
AAV-h-TAX1BP1

Ready-to-use AAV expressing Human TAX1BP1 (Tax1 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CALCOCO3; T6BP; Tax1 (human T-cell leukemia virus type I) binding protein 1; tax1-binding protein 1; TRAF6-binding protein; TXBP151
Description (eCommerce)
Tax1-binding protein 1 (TAX1BP1) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. TAX1BP1 is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86VP1].
Description (Vector)
TAX1BP1 encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
8887
Gene Name (eCommerce)
Tax1 binding protein 1
Gene Name (Vector)
Tax1 binding protein 1
Gene Symbol
TAX1BP1
HGNC ID
HGNC:11575
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2370
ORF Size (bp)
2370 bp
Protein Name (eCommerce)
Tax1-binding protein 1
RefSeq ID
NM_006024
RefSeq Synonyms
NM_006024, NM_001206902, NM_001206901, NM_001079864, BC050358,
Research Areas
Apoptosis,IFN Signaling,Immunology,Innate Immunity,Signal Transduction,TNF Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Tax1-binding protein 1 (TAX1BP1) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. TAX1BP1 is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86VP1].
UniGene ID
Hs.34576
UniProt ID (eCommerce)
Q86VP1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.