human SSR1 Over-expression AAV

Name 
AAV-h-SSR1
Cat No 
AAV-224396
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SSR1.

AAV-224396
AAV-h-SSR1

Ready-to-use AAV expressing Human SSR1 (signal sequence receptor subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
signal sequence receptor subunit alpha; signal sequence receptor, alpha; SSR alpha subunit; SSR-alpha; translocon-associated protein alpha subunit; translocon-associated protein subunit alpha; TRAP alpha; TRAPA; TRAP-alpha
Description (eCommerce)
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. SSR1/TRAP may be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P43307].
Description (Vector)
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical.
Gene ID
6745
Gene Name (eCommerce)
signal sequence receptor subunit 1
Gene Name (Vector)
signal sequence receptor subunit 1
Gene Symbol
SSR1
HGNC ID
HGNC:11323
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
861
Protein Name (eCommerce)
Translocon-associated protein subunit alpha
RefSeq ID
NM_003144
RefSeq Synonyms
NM_003144, NM_001292008, BC007710,
Research Areas
Gene Expression,Metabolism/Metabolic Process,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. SSR1/TRAP may be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P43307].
UniGene ID
Hs.114033
UniProt ID (eCommerce)
P43307

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.