human SPN Over-expression AAV

Name 
AAV-h-SPN
Cat No 
AAV-224211
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SPN.

AAV-224211
AAV-h-SPN

Ready-to-use AAV expressing Human SPN (sialophorin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD43; CD43; galactoglycoprotein; GALGP; GPL115; leukocyte sialoglycoprotein; leukosialin; LSN; Sialophorin; sialophorin (gpL115, leukosialin, CD43)
Description (eCommerce)
CD43 is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, CD43 is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune respons [taken from NCBI Entrez Gene (Gene ID: 6693)].
Description (Vector)
SPN is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response.
Gene ID
6693
Gene Name (eCommerce)
sialophorin
Gene Name (Vector)
sialophorin
Gene Symbol
SPN
HGNC ID
HGNC:11249
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1203
ORF Size (bp)
1203 bp
Protein Name (eCommerce)
Leukosialin
RefSeq ID
NM_003123
RefSeq Synonyms
NM_003123, NM_001030288, BC012350,
Research Areas
Cancer,Cardiovascular,Host-Virus Interactions,Immunology,Signal Transduction
Research Areas (Faceted)
cardiovascular,cancer,signal_transduction,infectious_disease,immunology
Species
human
Target Sentence
CD43 is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, CD43 is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune respons [taken from NCBI Entrez Gene (Gene ID: 6693)].
UniGene ID
Hs.632188
UniProt ID (eCommerce)
P16150

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.