human SIGLEC5 Over-expression AAV

Name 
AAV-h-SIGLEC5
Cat No 
AAV-222991
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SIGLEC5.

AAV-222991
AAV-h-SIGLEC5

Ready-to-use AAV expressing Human SIGLEC5 (sialic acid binding Ig like lectin 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5
Description (Vector)
SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Gene ID
8778
Gene Name (Vector)
sialic acid binding Ig like lectin 5
Gene Symbol
SIGLEC5
HGNC ID
HGNC:10874
ORF Size (aa)
1656
ORF Size (bp)
1656 bp
RefSeq ID
NM_003830
RefSeq Synonyms
NM_003830, BC029896,
Species
human
UniGene ID
Hs.310333

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.