human SFN Over-expression AAV

Name 
AAV-h-SFN
Cat No 
AAV-222774
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SFN.

AAV-222774
AAV-h-SFN

Ready-to-use AAV expressing Human SFN (stratifin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
14-3-3 protein sigma; epithelial cell marker protein 1; Stratifin; YWHAS
Description (eCommerce)
14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be downregulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.
Gene ID
2810
Gene Name (eCommerce)
stratifin
Gene Name (Vector)
stratifin
Gene Symbol
SFN
HGNC ID
HGNC:10773
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
747
ORF Size (bp)
747 bp
Protein Name (eCommerce)
14-3-3 protein sigma
RefSeq ID
NM_006142
RefSeq Synonyms
NM_006142, BC023552, BC002995, BC001550, BC000995, BC000329,
Research Areas
Apoptosis,Breast Cancer,Cancer,Cardiology,Cardiovascular,CD95/FAS Signaling,Cell Cycle,DNA Damage/Repair,FGF Signaling,FoxO Signaling,Immunology,LKB1 Signaling,MAPK Signaling,mTOR Signaling,NFAT Signaling,p53 Signaling,PDGF Signaling,PI3K/Akt Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be downregulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.
UniGene ID
Hs.523718
UniProt ID (eCommerce)
P31947

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.