human SENP7 Over-expression AAV

Name 
AAV-h-SENP7
Cat No 
AAV-222578
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SENP7.

AAV-222578
AAV-h-SENP7

Ready-to-use AAV expressing Human SENP7 (SUMO1/sentrin specific peptidase 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
sentrin/SUMO-specific protease SENP7; sentrin-specific protease 7; SUMO1/sentrin specific peptidase 7; SUMO-1-specific protease 2
Description (eCommerce)
Sentrin-specific protease 7 (SENP7) is a sumo protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but does not deconjugate SUMO1. SENP7 catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains and has very low efficiency in processing full-length SUMO proteins to their mature forms [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9BQF6].
Description (Vector)
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 (PubMed 18799455)).(supplied by OMIM, Jun 2009)
Gene ID
57337
Gene Name (eCommerce)
SUMO specific peptidase 7
Gene Name (Vector)
SUMO1/sentrin specific peptidase 7
Gene Symbol
SENP7
HGNC ID
HGNC:30402
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3153
ORF Size (bp)
3153 bp
Protein Name (eCommerce)
Sentrin-specific protease 7
RefSeq ID
NM_020654
RefSeq Synonyms
NM_020654, NM_001282804, NM_001282803, NM_001282802, NM_001282801, NM_001077203, BC129988,
Research Areas
Cell Biology,Ubiquitination
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Sentrin-specific protease 7 (SENP7) is a sumo protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but does not deconjugate SUMO1. SENP7 catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains and has very low efficiency in processing full-length SUMO proteins to their mature forms [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9BQF6].
UniGene ID
Hs.529551
UniProt ID (eCommerce)
Q9BQF6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.