human RDH8 Over-expression AAV

Name 
AAV-h-RDH8
Cat No 
AAV-220969
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RDH8.

AAV-220969
AAV-h-RDH8

Ready-to-use AAV expressing Human RDH8 (retinol dehydrogenase 8 (all-trans)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PRRDH; SDR28C2
Description (Vector)
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 (PubMed 10753906)). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 (PubMed 11710234)). This is a rate-limiting step in the visual cycle (Saari et al., 1998 (PubMed 9667000)).(supplied by OMIM, Mar 2008)
Gene ID
50700
Gene Name (Vector)
retinol dehydrogenase 8 (all-trans)
Gene Symbol
RDH8
HGNC ID
HGNC:14423
ORF Size (aa)
936
ORF Size (bp)
936 bp
RefSeq ID
NM_015725
RefSeq Synonyms
NM_015725, BC146479, BC140328,
Species
human
UniGene ID
Hs.675522

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.