human RASA4 Over-expression AAV

Name 
AAV-h-RASA4
Cat No 
AAV-220762
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RASA4.

AAV-220762
AAV-h-RASA4

Ready-to-use AAV expressing Human RASA4 (RAS p21 protein activator 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAPRI; GAPL
Description (Vector)
RASA4 encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
10156
Gene Name (Vector)
RAS p21 protein activator 4
Gene Symbol
RASA4
HGNC ID
HGNC:23181
ORF Size (aa)
2412
ORF Size (bp)
2412 bp
RefSeq ID
NM_006989
RefSeq Synonyms
NM_006989, NM_001079877, BC143584, BC113663, BC110873,
Species
human
UniGene ID
Hs.530089

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.