human RASA3 Over-expression AAV

Name 
AAV-h-RASA3
Cat No 
AAV-220760
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RASA3.

AAV-220760
AAV-h-RASA3

Ready-to-use AAV expressing Human RASA3 (RAS p21 protein activator 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GAP1IP4BP; GAPIII
Description (Vector)
RASA3 is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
Gene ID
22821
Gene Name (Vector)
RAS p21 protein activator 3
Gene Symbol
RASA3
HGNC ID
HGNC:20331
ORF Size (aa)
2505
ORF Size (bp)
2505 bp
RefSeq ID
NM_007368
RefSeq Synonyms
NM_007368, NM_001320822, NM_001320821, BC047242, BC038456,
Species
human
UniGene ID
Hs.593075

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.