human RABGEF1 Over-expression AAV

Name 
AAV-h-RABGEF1
Cat No 
AAV-220608
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RABGEF1.

AAV-220608
AAV-h-RABGEF1

Ready-to-use AAV expressing Human RABGEF1 (RAB guanine nucleotide exchange factor (GEF) 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
RAB guanine nucleotide exchange factor (GEF) 1; rab5 GDP/GTP exchange factor; rabaptin-5-associated exchange factor for Rab5; RABEX5; rabex-5; RAP1
Description (eCommerce)
RabGEF1 (Rab guanine nucleotide exchange factor 1) is a rab effector protein acting as linker between gamma-adaptin, Rab4A or Rab5A. RabGEF1 is involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. It stimulates nucleotide exchange on Rab5A. RabGEF1 can act as a ubiquitin ligase [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UJ41].
Description (Vector)
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 (PubMed 9323142)).(supplied by OMIM, Mar 2010)
Gene ID
27342
Gene Name (eCommerce)
RAB guanine nucleotide exchange factor 1
Gene Name (Vector)
RAB guanine nucleotide exchange factor (GEF) 1
Gene Symbol
RABGEF1
HGNC ID
HGNC:17676
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1476
ORF Size (bp)
1476 bp
Protein Name (eCommerce)
Rab5 GDP/GTP exchange factor
RefSeq ID
NM_014504
RefSeq Synonyms
NM_014504, NM_001287062, NM_001287061, NM_001287060, BC015330,
Research Areas
Transport,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
RabGEF1 (Rab guanine nucleotide exchange factor 1) is a rab effector protein acting as linker between gamma-adaptin, Rab4A or Rab5A. RabGEF1 is involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. It stimulates nucleotide exchange on Rab5A. RabGEF1 can act as a ubiquitin ligase [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UJ41].
UniGene ID
Hs.530053
UniProt ID (eCommerce)
Q9UJ41

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.