human QARS Over-expression AAV
This is an AAV expressing Human QARS.
AAV-220462
AAV-h-QARS
Ready-to-use AAV expressing Human QARS (glutaminyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GLNRS; glutamine--tRNA ligase; glutamine-tRNA synthetase; Glutaminyl-tRNA synthetase; MSCCA; PRO2195
Description (eCommerce)
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants [taken from NCBI Entrez Gene (Gene ID: 5859)].
Description (Vector)
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.
Gene ID
5859
Gene Name (eCommerce)
glutaminyl-tRNA synthetase
Gene Name (Vector)
glutaminyl-tRNA synthetase
Gene Symbol
QARS
HGNC ID
HGNC:9751
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2328
ORF Size (bp)
2328 bp
Protein Name (eCommerce)
Glutamine--tRNA ligase
RefSeq ID
NM_005051
RefSeq Synonyms
NM_005051, NM_001272073, BC029739, BC016634, BC001772, BC001567, BC000394,
Research Areas
Gene Expression,Metabolism/Metabolic Process,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants [taken from NCBI Entrez Gene (Gene ID: 5859)].
UniGene ID
Hs.79322
UniProt ID (eCommerce)
P47897
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.