human PVRL1 Over-expression AAV

Name 
AAV-h-PVRL1
Cat No 
AAV-220417
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NECTIN1.

AAV-220417
AAV-h-PVRL1

Ready-to-use AAV expressing Human NECTIN1 (nectin cell adhesion molecule 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD111;CD111;CLPED1;ectodermal dysplasia 4 (Margarita Island type);ED4;herpes simplex virus type 1 sensitivity;herpes virus entry mediator C;Herpesvirus entry mediator C;herpesvirus Ig-like receptor;HIgR;HV1S;HVEC;nectin 1;Nectin cell adhesion molecule 1;nectin-1;OFC7;poliovirus receptor-like 1;poliovirus receptor-related 1 (herpesvirus entry mediator C);poliovirus receptor-related protein 1;PRR;PRR1;PVRL1;PVRR;PVRR1;SK-12
Description (eCommerce)
PVRL1/NECTIN1 (aka CD111) is an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily. It acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2) and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells [taken from NCBI Entrez Gene (Gene ID: 5818)].
Description (Vector)
PVRL1 encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Gene ID
5818
Gene Name (eCommerce)
nectin cell adhesion molecule 1
Gene Name (Vector)
nectin cell adhesion molecule 1
Gene Symbol
NECTIN1
HGNC ID
HGNC:9706
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1554
ORF Size (bp)
1554 bp
Protein Name (eCommerce)
Nectin-1
RefSeq ID
NM_002855
RefSeq Synonyms
NM_203286, NM_203285, NM_002855, BC113471, BC104948,
Research Areas
Axon Guidance,Cell Biology,Cytoskeleton,EGFR Signaling,Immunology,Neurobiology,Signal Transduction,Synapse,Translational Control,Transport
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PVRL1/NECTIN1 (aka CD111) is an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily. It acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2) and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells [taken from NCBI Entrez Gene (Gene ID: 5818)].
UniGene ID
Hs.334846
UniProt ID (eCommerce)
Q15223

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.