human PTRH2 Over-expression AAV

Name 
AAV-h-PTRH2
Cat No 
AAV-220370
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PTRH2.

AAV-220370
AAV-h-PTRH2

Ready-to-use AAV expressing Human PTRH2 (peptidyl-tRNA hydrolase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bcl-2 inhibitor of transcription 1; BIT1; CFAP37; CGI-147; cilia and flagella associated protein 37; IMNEPD; peptidyl-tRNA hydrolase 2, mitochondrial; PTH; PTH 2; PTH2
Description (eCommerce)
Peptidyl-tRNA hydrolase 2 (PTRH2) is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos [taken from NCBI Entrez Gene (Gene ID: 51651)].
Gene ID
51651
Gene Name (eCommerce)
peptidyl-tRNA hydrolase 2
Gene Name (Vector)
peptidyl-tRNA hydrolase 2
Gene Symbol
PTRH2
HGNC ID
HGNC:24265
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
540
ORF Size (bp)
540 bp
Protein Name (eCommerce)
Peptidyl-tRNA hydrolase 2, mitochondrial
RefSeq ID
NM_016077
RefSeq Synonyms
NM_016077, NM_001015509, BC006807,
Research Areas
Apoptosis,Gene Expression,Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Peptidyl-tRNA hydrolase 2 (PTRH2) is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos [taken from NCBI Entrez Gene (Gene ID: 51651)].
UniGene ID
Hs.12677
UniProt ID (eCommerce)
Q9Y3E5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.