human PSMD13 Over-expression AAV

26S proteasome non-ATPase regulatory subunit 13; 26S proteasome regulatory subunit p40.5; 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome subunit p40.5; HSPC027; p40.5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13; Rpn9; S11

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 (PSMD13) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD13 is a non-ATPase subunit of the 19S regulator. [taken from NCBI Entrez Gene (Gene ID: 5719)].

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described.

5719

proteasome 26S subunit, non-ATPase 13

proteasome 26S subunit, non-ATPase 13

PSMD13

HGNC:9558

9606.0

1131

26S proteasome non-ATPase regulatory subunit 13

NM_002817

NM_175932, NM_002817, BC001747, BC001100,

Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Cell Division,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Meiosis,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,NF-kB Signaling,Notch Signaling,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling

cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation

human

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 (PSMD13) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD13 is a non-ATPase subunit of the 19S regulator. [taken from NCBI Entrez Gene (Gene ID: 5719)].

Hs.134688

Q9UNM6