human PSMA2 Over-expression AAV

Name 
AAV-h-PSMA2
Cat No 
AAV-220093
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PSMA2.

AAV-220093
AAV-h-PSMA2

Ready-to-use AAV expressing Human PSMA2 (proteasome subunit alpha 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HC3; macropain subunit C3; MU; multicatalytic endopeptidase complex subunit C3; PMSA2; proteasome (prosome, macropain) subunit, alpha type, 2; proteasome component C3; proteasome subunit alpha type-2; proteasome subunit HC3; PSC2
Description (eCommerce)
Proteasome (prosome, macropain) subunit, alpha type, 2 (PSMA2) is a component of the proteasome, a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA2 is a member of the peptidase T1A family, that is a 20S core alpha subunit [taken from NCBI Entrez Gene (Gene ID: 5683)].
Description (Vector)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
Gene ID
5683
Gene Name (eCommerce)
proteasome subunit alpha 2
Gene Name (Vector)
proteasome subunit alpha 2
Gene Symbol
PSMA2
HGNC ID
HGNC:9531
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
705
Protein Name (eCommerce)
Proteasome subunit alpha type-2
RefSeq ID
NM_002787
RefSeq Synonyms
NM_002787, BC047697,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Cell Division,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Metabolism/Metabolic Process,NF-kB Signaling,Notch Signaling,Proteasome,Response to Virus,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,metabolism,signal_transduction,immunology,developmental_biology,cell_biology,infectious_disease,genetics,transcription_translation,signal_transduction,immunology,genetics,developmental_biology
Species
human
Target Sentence
Proteasome (prosome, macropain) subunit, alpha type, 2 (PSMA2) is a component of the proteasome, a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA2 is a member of the peptidase T1A family, that is a 20S core alpha subunit [taken from NCBI Entrez Gene (Gene ID: 5683)].
UniGene ID
Hs.333786
UniProt ID (eCommerce)
P25787

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.