human PSENEN Over-expression AAV

Name 
AAV-h-PSENEN
Cat No 
AAV-220069
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PSENEN.

AAV-220069
AAV-h-PSENEN

Ready-to-use AAV expressing Human PSENEN (presenilin enhancer gamma-secretase subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MDS033; MSTP064; PEN-2; PEN2
Description (Vector)
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Gene ID
55851
Gene Name (Vector)
presenilin enhancer gamma-secretase subunit
Gene Symbol
PSENEN
HGNC ID
HGNC:30100
ORF Size (aa)
306
RefSeq ID
NM_172341
RefSeq Synonyms
NM_172341, NM_001281532, BC009575,
Species
human
UniGene ID
Hs.534465

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.