human UBAP1 Over-expression AAV

Name 
AAV-h-UBAP1
Cat No 
AAV-219916
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human UBAP1.

AAV-219916
AAV-h-UBAP1

Ready-to-use AAV expressing Human UBAP1 (ubiquitin associated protein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
NAG20; nasopharyngeal carcinoma-associated gene 20 protein; UAP; UBAP; UBAP-1; ubiquitin-associated protein 1
Description (eCommerce)
Ubiquitin-associated protein 1 (UBAP1) is a component of the ESCRT-I complex, a regulator of vesicular trafficking process. It binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). It plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZ09].
Description (Vector)
UBAP1 is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
51271
Gene Name (eCommerce)
ubiquitin associated protein 1
Gene Name (Vector)
ubiquitin associated protein 1
Gene Symbol
UBAP1
HGNC ID
HGNC:12461
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1509
ORF Size (bp)
1509 bp
Protein Name (eCommerce)
Ubiquitin-associated protein 1
RefSeq ID
NM_016525
RefSeq Synonyms
NM_016525, NM_001171204, NM_001171203, NM_001171202, NM_001171201, BC100668, BC099726, BC098316, BC098141, BC020950,
Research Areas
Cell Biology,Translational Control,Transport
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Ubiquitin-associated protein 1 (UBAP1) is a component of the ESCRT-I complex, a regulator of vesicular trafficking process. It binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). It plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZ09].
UniGene ID
Hs.268963
UniProt ID (eCommerce)
Q9NZ09

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.