human PDPK1 Over-expression AAV

Name 
AAV-h-PDPK1
Cat No 
AAV-219915
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PDPK1.

AAV-219915
AAV-h-PDPK1

Ready-to-use AAV expressing Human PDPK1 (3-phosphoinositide dependent protein kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; hPDK1; PDK1; PDPK2; PDPK2P; PkB kinase like gene 1; PRO0461
Description (eCommerce)
PDK1 (3-phosphoinositide-dependent kinase-1) is a serine/threonine kinase that contains a PH domain for binding of phosphatidylinositols (PtdIns). PDK1 phosphorylates PKB/AKT in response to agonist stimulation of phosphoinositide 3-kinases (PI3Ks). Stimulation of PI3Ks generates specific inositol lipids that are important for activation of PDK1. PDK1 may also be responsible for phosphorylating PKA, PKC-zeta, RPS6KA1, and RPS6KB1.
Gene ID
5170
Gene Name (eCommerce)
3-phosphoinositide dependent protein kinase 1
Gene Name (Vector)
3-phosphoinositide dependent protein kinase 1
Gene Symbol
PDPK1
HGNC ID
HGNC:8816
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1671
ORF Size (bp)
1671 bp
Protein Name (eCommerce)
3-phosphoinositide-dependent protein kinase 1
RefSeq ID
NM_002613
RefSeq Synonyms
NM_031268, NM_002613, NM_001261816, BC033494, BC012103, BC006339,
Research Areas
Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD95/FAS Signaling,Cell Cycle,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,GPCR Signaling,HGF Signaling,Host-Virus Interactions,Hypoxia,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Lung Cancer,mTOR Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TRKA Signaling,TSH Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
PDK1 (3-phosphoinositide-dependent kinase-1) is a serine/threonine kinase that contains a PH domain for binding of phosphatidylinositols (PtdIns). PDK1 phosphorylates PKB/AKT in response to agonist stimulation of phosphoinositide 3-kinases (PI3Ks). Stimulation of PI3Ks generates specific inositol lipids that are important for activation of PDK1. PDK1 may also be responsible for phosphorylating PKA, PKC-zeta, RPS6KA1, and RPS6KB1.
UniGene ID
Hs.459691
UniProt ID (eCommerce)
O15530

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.