human PRKRIR Over-expression AAV

Name 
AAV-h-PRKRIR
Cat No 
AAV-219879
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human THAP12.

AAV-219879
AAV-h-PRKRIR

Ready-to-use AAV expressing Human THAP12 (THAP domain containing 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
52 kDa repressor of the inhibitor of the protein kinase; 58 kDa interferon-induced protein kinase-interacting protein; DAP4; death-associated protein 4; inhibitor of protein kinase PKR; P52rIPK; p58IPK-interacting protein; P58IPK-regulatory protein; PRKRIR; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); testicular tissue protein Li 133; THAP domain-containing protein 0; THAP domain-containing protein 12; THAP0
Description (eCommerce)
P58IPK is an inhibitor of the serine/threonine protein kinase, PKR. P58IPK functions to repress eukaryotic initiation factor 2-alpha subunit (eIF-2alpha) phosphorylation by PKR. PRKRIR, also designated P52RIPK, is a P58IPK interacting protein that abrogates P58IPK mediated suppression of PKR activity.
Gene ID
5612
Gene Name (eCommerce)
THAP domain containing 12
Gene Name (Vector)
THAP domain containing 12
Gene Symbol
THAP12
HGNC ID
HGNC:9440
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2286
ORF Size (bp)
2286 bp
Protein Name (eCommerce)
52 kDa repressor of the inhibitor of the protein kinase
RefSeq ID
NM_004705
RefSeq Synonyms
NM_004705, BC117140, BC117138, BC110304,
Research Areas
Cell Biology,Signal Transduction,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
P58IPK is an inhibitor of the serine/threonine protein kinase, PKR. P58IPK functions to repress eukaryotic initiation factor 2-alpha subunit (eIF-2alpha) phosphorylation by PKR. PRKRIR, also designated P52RIPK, is a P58IPK interacting protein that abrogates P58IPK mediated suppression of PKR activity.
UniGene ID
Hs.503315
UniProt ID (eCommerce)
O43422

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.