human POU3F2 Over-expression AAV

Name 
AAV-h-POU3F2
Cat No 
AAV-219477
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human POU3F2.

AAV-219477
AAV-h-POU3F2

Ready-to-use AAV expressing Human POU3F2 (POU class 3 homeobox 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
brain-2; brain-specific homeobox/POU domain protein 2; BRN2; brn-2; nervous system-specific octamer-binding transcription factor N-Oct-3; N-Oct3; OCT7; oct-7; octamer-binding protein 7; octamer-binding transcription factor 7; OTF7; OTF-7; POU domain, class 3, transcription factor 2; POUF3
Description (eCommerce)
Brain-specific homeobox/POU domain protein 2, (Brn-2) is a transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Brn-2 positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P20265].
Description (Vector)
POU3F2 encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells.
Gene ID
5454
Gene Name (eCommerce)
POU class 3 homeobox 2
Gene Name (Vector)
POU class 3 homeobox 2
Gene Symbol
POU3F2
HGNC ID
HGNC:9215
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1332
ORF Size (bp)
1332 bp
Protein Name (eCommerce)
POU domain, class 3, transcription factor 2
RefSeq ID
NM_005604
RefSeq Synonyms
NM_005604, BC051699,
Research Areas
Axonogenesis,Neurobiology,Neurodevelopment,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Brain-specific homeobox/POU domain protein 2, (Brn-2) is a transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Brn-2 positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P20265].
UniGene ID
Hs.182505
UniProt ID (eCommerce)
P20265

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.