human PHGDH Over-expression AAV

Name 
AAV-h-PHGDH
Cat No 
AAV-218825
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PHGDH.

AAV-218825
AAV-h-PHGDH

Ready-to-use AAV expressing Human PHGDH (phosphoglycerate dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2-oxoglutarate reductase; 3PGDH; 3-PGDH; 3-phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase; epididymis secretory protein Li 113; HEL-S-113; malate dehydrogenase; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA
Description (eCommerce)
D-3-phosphoglycerate dehydrogenase (PHGDH) is an enzyme involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptom [taken from NCBI Entrez Gene (Gene ID: 26227)].
Description (Vector)
PHGDH encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.
Gene ID
26227
Gene Name (eCommerce)
phosphoglycerate dehydrogenase
Gene Name (Vector)
phosphoglycerate dehydrogenase
Gene Symbol
PHGDH
HGNC ID
HGNC:8923
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1602
ORF Size (bp)
1602 bp
Protein Name (eCommerce)
D-3-phosphoglycerate dehydrogenase
RefSeq ID
NM_006623
RefSeq Synonyms
NM_006623, BC011262, BC001349, BC000303,
Research Areas
Brain Development,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,neurobiology
Species
human
Target Sentence
D-3-phosphoglycerate dehydrogenase (PHGDH) is an enzyme involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptom [taken from NCBI Entrez Gene (Gene ID: 26227)].
UniGene ID
Hs.487296
UniProt ID (eCommerce)
O43175

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.