human PHB2 Over-expression AAV

Name 
AAV-h-PHB2
Cat No 
AAV-218786
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PHB2.

AAV-218786
AAV-h-PHB2

Ready-to-use AAV expressing Human PHB2 (prohibitin 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BAP; Bap37; BCAP37; B-cell associated protein; B-cell receptor-associated protein BAP37; D-prohibitin; hBAP; p22; PNAS-141; prohibitin-2; REA; repressor of estrogen receptor activitY
Description (eCommerce)
REA (repressor of estrogen receptor activity), also known as prohibitin 2, has been shown to exhibit a variety of functions that includes mitochondrial chaperone activity, cell cycle regulation, and transcriptional regulation. REA localizes to the mitochondria and associates with mitochondrial complex I where it may play a role in mitochondrial metabolism. REA interacts with pRb to inhibit E2F-mediated transcription as well as the estrogen receptor to repress estrogen-dependent transcription via recruitment of histone deacetylases.
Gene ID
11331
Gene Name (eCommerce)
prohibitin 2
Gene Name (Vector)
prohibitin 2
Gene Symbol
PHB2
HGNC ID
HGNC:30306
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
900
ORF Size (bp)
900 bp
Protein Name (eCommerce)
Prohibitin-2
RefSeq ID
NM_007273
RefSeq Synonyms
NM_007273, NM_001267700, NM_001144831, BC110322, BC014766,
Research Areas
Estrogen Signaling,Mitochondrion,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
REA (repressor of estrogen receptor activity), also known as prohibitin 2, has been shown to exhibit a variety of functions that includes mitochondrial chaperone activity, cell cycle regulation, and transcriptional regulation. REA localizes to the mitochondria and associates with mitochondrial complex I where it may play a role in mitochondrial metabolism. REA interacts with pRb to inhibit E2F-mediated transcription as well as the estrogen receptor to repress estrogen-dependent transcription via recruitment of histone deacetylases.
UniGene ID
Hs.504620
UniProt ID (eCommerce)
Q99623

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.