human PCSK9 Over-expression AAV

Name 
AAV-h-PCSK9
Cat No 
AAV-218414
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PCSK9.

AAV-218414
AAV-h-PCSK9

Ready-to-use AAV expressing Human PCSK9 (proprotein convertase subtilisin/kexin type 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
convertase subtilisin/kexin type 9 preproprotein; FH3; HCHOLA3; LDLCQ1; NARC1; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; PC9; Proprotein convertase 9; proprotein convertase subtilisin/kexin type 9; subtilisin/kexin-like protease PC9
Description (eCommerce)
The gene PCSK9, also known as NARC1, encodes for proprotein convertase subtilisin/kexin type 9. A member of the subtilisin-like proprotein convertase family, this protein is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia [taken from NCBI Entrez Gene (Gene ID: 255738)].
Description (Vector)
PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Gene ID
255738
Gene Name (eCommerce)
proprotein convertase subtilisin/kexin type 9
Gene Name (Vector)
proprotein convertase subtilisin/kexin type 9
Gene Symbol
PCSK9
HGNC ID
HGNC:20001
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2079
ORF Size (bp)
2079 bp
Protein Name (eCommerce)
Proprotein convertase subtilisin/kexin type 9
RefSeq ID
NM_174936
RefSeq Synonyms
NM_174936, BC166619,
Research Areas
Apoptosis,Golgi Apparatus,Lysosomal Transport,Lysosome,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
The gene PCSK9, also known as NARC1, encodes for proprotein convertase subtilisin/kexin type 9. A member of the subtilisin-like proprotein convertase family, this protein is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia [taken from NCBI Entrez Gene (Gene ID: 255738)].
UniGene ID
Hs.18844
UniProt ID (eCommerce)
Q8NBP7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.