human PCSK2 Over-expression AAV

Name 
AAV-h-PCSK2
Cat No 
AAV-218410
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PCSK2.

AAV-218410
AAV-h-PCSK2

Ready-to-use AAV expressing Human PCSK2 (proprotein convertase subtilisin/kexin type 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
NEC 2; NEC-2; NEC2; PC2; SPC2
Description (Vector)
PCSK2 encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. PCSK2 may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
5126
Gene Name (Vector)
proprotein convertase subtilisin/kexin type 2
Gene Symbol
PCSK2
HGNC ID
HGNC:8744
ORF Size (aa)
1860
ORF Size (bp)
1860 bp
RefSeq ID
NM_002594
RefSeq Synonyms
NM_002594, NM_001201529, NM_001201528, BC040546, BC005815,
Species
human
UniGene ID
Hs.315186

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.