human PAXIP1 Over-expression AAV

Name 
AAV-h-PAXIP1
Cat No 
AAV-218284
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PAXIP1.

AAV-218284
AAV-h-PAXIP1

Ready-to-use AAV expressing Human PAXIP1 (PAX interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAGF28; CAGF29; PACIP1; PAX interacting (with transcription-activation domain) protein 1; PAX transactivation activation domain-interacting protein; PAX transcription activation domain interacting protein 1 like; PAX-interacting protein 1; PAXIP1L; protein encoded by CAG trinucleotide repeats; PTIP; TNRC2
Description (eCommerce)
Pax transactivation domain-interacting protein (PTIP) is implicated in the DNA damage response. PTIP interacts with 53BP1 and PA1 and is part of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, a novel protein PA-1 MLL3, MLL4, and UTX. PTIP is therefore suggested to have a role in the regulation of gene expression.
Description (Vector)
PAXIP1 is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.
Gene ID
22976
Gene Name (eCommerce)
PAX interacting protein 1
Gene Name (Vector)
PAX interacting protein 1
Gene Symbol
PAXIP1
HGNC ID
HGNC:8624
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2274
ORF Size (bp)
2274 bp
Protein Name (eCommerce)
PAX-interacting protein 1
RefSeq ID
NM_007349
RefSeq Synonyms
NM_007349, BC033781,
Research Areas
Cardiovascular,DNA Damage/Repair,Histone Modification,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Pax transactivation domain-interacting protein (PTIP) is implicated in the DNA damage response. PTIP interacts with 53BP1 and PA1 and is part of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, a novel protein PA-1 MLL3, MLL4, and UTX. PTIP is therefore suggested to have a role in the regulation of gene expression.
UniGene ID
Hs.443881
UniProt ID (eCommerce)
Q6ZW49

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.