human PATZ1 Over-expression AAV

Name
AAV-h-PATZ1

Cat No
AAV-218266

Availability
4-5 weeks

This is an AAV expressing Human PATZ1.

AAV-218266

AAV-h-PATZ1

Ready-to-use AAV expressing Human PATZ1 (POZ/BTB and AT hook containing zinc finger 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG

Description (Vector)

PATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Gene ID

23598

Gene Name (Vector)

POZ/BTB and AT hook containing zinc finger 1

Gene Symbol

PATZ1

HGNC ID

HGNC:13071

ORF Size (aa)

1614

ORF Size (bp)

1614 bp

RefSeq ID

NM_014323

RefSeq Synonyms

NM_032052, NM_032051, NM_032050, NM_014323, BC021091,

Species

human

UniGene ID

Hs.517557

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.