rat PECAM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Pecam1.
shADV-294722
Ad-r-PECAM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Pecam1 (platelet and endothelial cell adhesion molecule 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD31; Pecam
Description (Vector)
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
Gene ID
29583
Gene Name (Vector)
platelet and endothelial cell adhesion molecule 1
Gene Symbol
Pecam1
ORF Size (aa)
2037
ORF Size (bp)
2037 bp
RefSeq ID
NM_031591
RefSeq Synonyms
NM_031591, BC104711,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.