rat IL1RAP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Il1rap.
shADV-294612
Ad-r-IL1RAP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Il1rap (interleukin 1 receptor accessory protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IL-1RAcp; Il1racpb
Description (Vector)
Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Gene ID
25466
Gene Name (Vector)
interleukin 1 receptor accessory protein
Gene Symbol
Il1rap
ORF Size (aa)
1083
ORF Size (bp)
1083 bp
RefSeq ID
NM_001167840
RefSeq Synonyms
NM_012968, NM_001167840, BC097339,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.