rat NSMCE1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Nsmce1.
shADV-294413
Ad-r-NSMCE1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Nsmce1 (NSE1 homolog, SMC5-SMC6 complex component). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RGD1307760
Description (Vector)
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.
Gene ID
361645
Gene Name (Vector)
NSE1 homolog, SMC5-SMC6 complex component
Gene Symbol
Nsmce1
ORF Size (aa)
873
ORF Size (bp)
873 bp
RefSeq ID
NM_001039611
RefSeq Synonyms
NM_001039611, BC099757,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.