rat NEIL1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Neil1.
shADV-294318
Ad-r-NEIL1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Neil1 (nei-like DNA glycosylase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
Gene ID
367090
Gene Name (Vector)
nei-like DNA glycosylase 1
Gene Symbol
Neil1
ORF Size (aa)
1164
ORF Size (bp)
1164 bp
RefSeq ID
NM_001025754
RefSeq Synonyms
NM_001025754, BC099125,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.