rat DCLRE1B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Dclre1b.
shADV-294279
Ad-r-DCLRE1B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Dclre1b (DNA cross-link repair 1B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Gene ID
310745
Gene Name (Vector)
DNA cross-link repair 1B
Gene Symbol
Dclre1b
ORF Size (aa)
930
ORF Size (bp)
930 bp
RefSeq ID
NM_001025687
RefSeq Synonyms
NM_001025687, BC098939,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.