rat A2M shRNA silencing Adenovirus

Name
Ad-r-A2M-shRNA

Cat No
shADV-294270

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Rat A2m.

shADV-294270

Ad-r-A2M-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat A2m (alpha-2-macroglobulin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

A2m1; A2maa; A2MAC1; A2mb; Mam

Description (Vector)

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene ID

24153

Gene Name (Vector)

alpha-2-macroglobulin

Gene Symbol

A2m

ORF Size (aa)

4419

ORF Size (bp)

4419 bp

RefSeq ID

NM_012488

RefSeq Synonyms

NM_012488, BC098922,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.