rat BLNK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Blnk.
shADV-294174
Ad-r-BLNK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Blnk (B-cell linker). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Gene ID
499356
Gene Name (Vector)
B-cell linker
Gene Symbol
Blnk
ORF Size (aa)
1374
ORF Size (bp)
1374 bp
RefSeq ID
NM_001025767
RefSeq Synonyms
NM_001025767, BC098790,
Species
rat
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.