rat PSME3 shRNA silencing Adenovirus

Name
Ad-r-PSME3-shRNA

Cat No
shADV-292850

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Psme3.

shADV-292850

Ad-r-PSME3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Psme3 (proteasome activator subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Ab2-371

Description (Vector)

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Gene ID

287716

Gene Name (Vector)

proteasome activator subunit 3

Gene Symbol

Psme3

ORF Size (aa)

765

RefSeq ID

NM_001011894

RefSeq Synonyms

NM_001011894, BC089889,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.