rat CLP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Clp1.
shADV-292509
Ad-r-CLP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Clp1 (cleavage and polyadenylation factor I subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Heab; RGD1307679
Description (Vector)
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
Gene ID
311166
Gene Name (Vector)
cleavage and polyadenylation factor I subunit 1
Gene Symbol
Clp1
ORF Size (aa)
1278
ORF Size (bp)
1278 bp
RefSeq ID
NM_001009599
RefSeq Synonyms
NM_001009599, BC087130,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.