rat PDE12 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Pde12.
shADV-291994
Ad-r-PDE12-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Pde12 (phosphodiesterase 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LRRGT00074; RGD1310975
Description (Vector)
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Gene ID
306231
Gene Name (Vector)
phosphodiesterase 12
Gene Symbol
Pde12
ORF Size (aa)
1827
ORF Size (bp)
1827 bp
RefSeq ID
NM_001013998
RefSeq Synonyms
NM_001013998, BC079396,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.