rat VISA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Mavs.
shADV-291851
Ad-r-VISA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Mavs (mitochondrial antiviral signaling protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Visa
Description (Vector)
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
Gene ID
311430
Gene Name (Vector)
mitochondrial antiviral signaling protein
Gene Symbol
Mavs
ORF Size (aa)
1524
ORF Size (bp)
1524 bp
RefSeq ID
NM_001005556
RefSeq Synonyms
NM_001005556, BC081869,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.