rat MBD1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Mbd1.
shADV-290752
Ad-r-MBD1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Mbd1 (methyl-CpG binding domain protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Gene ID
291439
Gene Name (Vector)
methyl-CpG binding domain protein 1
Gene Symbol
Mbd1
ORF Size (aa)
1602
ORF Size (bp)
1602 bp
RefSeq ID
NM_001011924
RefSeq Synonyms
NM_001011924, BC081932,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.