rat AIFM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Aifm1.
shADV-290718
Ad-r-AIFM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Aifm1 (apoptosis inducing factor, mitochondria associated 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Aif; Pdcd8
Description (Vector)
Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Gene ID
83533
Gene Name (Vector)
apoptosis inducing factor, mitochondria associated 1
Gene Symbol
Aifm1
ORF Size (aa)
1839
ORF Size (bp)
1839 bp
RefSeq ID
NM_031356
RefSeq Synonyms
NM_031356, BC072697,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.