rat SKP1 shRNA silencing Adenovirus

Name
Ad-r-SKP1-shRNA

Cat No
shADV-290143

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Skp1.

shADV-290143

Ad-r-SKP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Skp1 (S-phase kinase-associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Skp1a

Description (Vector)

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.

Gene ID

287280

Gene Name (Vector)

S-phase kinase-associated protein 1

Gene Symbol

Skp1

ORF Size (aa)

492

RefSeq ID

NM_001007608

RefSeq Synonyms

NM_001007608, BC058152,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.