mouse NR2F6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nr2f6.
shADV-278503
Ad-m-NR2F6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nr2f6 (nuclear receptor subfamily 2, group F, member 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AV090102; COUP-TF3; EAR2; Erbal2
Description (Vector)
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Gene ID
13864
Gene Name (Vector)
nuclear receptor subfamily 2, group F, member 6
Gene Symbol
Nr2f6
ORF Size (aa)
1173
RefSeq ID
NM_010150
RefSeq Synonyms
NM_010150, BC008138,
Species
mouse
UniGene ID
Mm.28989
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.