human NR1I2 Over-expression AAV

Name
AAV-h-NR1I2

Cat No
AAV-217039

Availability
4-5 weeks

This is an AAV expressing Human NR1I2.

AAV-217039

AAV-h-NR1I2

Ready-to-use AAV expressing Human NR1I2 (nuclear receptor subfamily 1 group I member 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR

Description (Vector)

NR1I2 product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Gene ID

8856

Gene Name (Vector)

nuclear receptor subfamily 1 group I member 2

Gene Symbol

NR1I2

HGNC ID

HGNC:7968

ORF Size (aa)

1302

ORF Size (bp)

1302 bp

RefSeq ID

NM_003889

RefSeq Synonyms

NM_033013, NM_022002, NM_003889, BC017304,

Species

human

UniGene ID

Hs.7303

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.